How do you play PoE?

Curse - always on E

Movement skill ( if any ) - W

about the others it's totally random depending on what main skill i use

for example when i play melee chars Q is my go to main attack always , when i'm on my caster though right mouse is where it's at .

RMB single target attack
MMB AoE attack
LMB - move (mostly) sometimes a ranged attack
A - move (sometimes) - sometimes curses too
S - traps
D - Totems
intead of F I have MB5 (side mouse button) for minions or curses
G - auras/portal