Game crashes when I click "League" in character creation.

Go to the Add/Remove Programs and uninstall all the Microsoft VC Runtimes.

Then go to the Path of Exile install folder and find the Setup folder in there and look for a program called vcredist.exe I believe. Run it by right-clicking and selecting "Run as Administrator"
Do I reinstall Microsoft runtime at all?
I am also having issues finding that exe you linked I went to open file location for the short cut and was looking through those files.
yeah. looks like the file isn't where I thought it was.

download the correct one from this site
Okay so I downloaded that from Microsoft.
Right-click the download and select "Run as Administrator" to install it, then try PoE again and report results?
Tried it and no results...same crash at clicking league..every single...damn time. I guess I wasn't meant to play this game or something...kinda depressing since I don't see any other games similar to diablo 2.
Same crash with the same error and the same file?

When was the last time you reinstalled your operating system?

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