Giant's Blood: Can't wield in two hands

After taking Giant's Blood you lose the option to equip a two-handed mace in two hands- you can only one hand it.

That's how it works, the two-handed weapons are equipped in one hand with Giant Blood.

You can wield Two-Handed Axes, Maces and Swords in one hand

I agree "can" may sound misleading, like it lets you a choice. Ideally, Giant's Blood should provide this option and revert the requirements back to normal. But it doesn't seem technically feasible.