Completing all achievements is currently impossible in ruthless mode, due to removed mechanics.

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KatCut wrote:

I wanted to do a challenge run where I complete all achievements in the game but in ruthless mode. However they were not yet updated to the ruthless mode, and still require things that are inaccessible to ruthless players. For example, no stone unturned currently require 140 points to complete and the story glyphs in vaal side areas count for those 140 story glyphs you must read, but vaal side areas do not exist in ruthless mode, not even if you try to open a sacrifice fragment in the map device, it doesn't open a vaal side area. Furthermore, the achievement that requires all pantheon powers upgraded is impossible, due to the pantheon system not even being present in ruthless at all. This could be solved by removing the requirement for these achievements for ruthless mode only or making the glyphs available some other way. Though this is not a high priority issue I do feel like it is important for the achievements to be completable in all game modes. There might be others I don`t know of yet. Another way is to create a separate list of achievements for ruthless that don't interfere with the regular game mode achievements. And no I do not mean challenges I mean actual achievements that are available in all leagues including standard. Those that show up on steam when u complete them.

Even if I may never realistically complete all challenges that are available in ruthless mode it is still incredibly motivating for me to have something as long term as this to work towards.