Help me understand attack speed and skills

So attack skills don't have a cast speed, they take as long to cast as it takes to make an attack with the weapon you are holding (not sure how dual wield factors into this)?

Some builds I looked at in PoB achieve Attacks-Per-Second in the 3 to 5 range, does that mean I have to spam the key on my keyboard 3 to 5 times per second to achieve the maximum DPS?

Is this not limited by the graphic animations? Any tips on how do to sustain this level of spamming a key for hours running through maps without carpal tunnel crippling your hand?

The attacks or spells will repeat as long as you hold down the button. No worries there.

Remember that attack skills also have attack speed adjustment. For example, Earthquake has attack speed 75% of base, meaning the attack will be slower than normal, and this adjustment is multiplicative to other attack speed modifiers. For example, dual wielding grants 15% more attack speed.

You know what they say,
Mo attacks,
Mo problems.