Last Rites > all (by a huge margin)

I think Last Rites is the single most powerful node in the game.

Pseudo-damage-wise nothing can even come close and defence-wise it is great too.

Enemies Cursed by you have a 50% reduced Life Regeneration Rate
Since almost every enemy mob and their grandmother has 20 gazillion life regen these days this part alone can be better than a few million regular dps. Ever encountered an AN-mob with resist your element plus gigachad regen? Those guys can sometimes be completely unkillable if your character isn't completely op. But with Last Rites np.

Cursed Enemies you Kill are destroyed
Since you always should curse your enemies there is never again a problem with exploding corpses or other nasty shit like this.

Enemies you Curse cannot Recharge Energy Shield
Isn't the greatest thing since sliced bread but still nice to have.

Even if you are not close to the node name another node that can do so much for you so that you would choose another anointment.