Is there a way to lock interface so that it become unclickable during fights?

I remember in WoW there was an option to lock interface.

And I played Lost Ark a little and it has an option to lock interface during fights.

Is there a way to lock interface in PoE? Some addon maybe?

"Add-ons" that modify gamefiles are against the ToS and there is no API as far as I am aware. The best that could be done would be image recognition and preventing mouse clicks when there is a mechanic you would click rather than accidentally clicking the mechanic, but realistically it would be best to request this functionality from GGG instead.

For now, you can hide labels ('Z' by default), which will hide some mechanics and make others smaller, but you would still be able to click them on accident. The other downside is that your loot is hidden that way, but you can use this if you want to concentrate on fighting first.