Can't open chests or interact with strong boxes or metamorph encounters 50% of the time.

This is only a problem on my summoner. It's very frustrating because I'm forced to miss a lot of stuff. It has even happened in the labyrinth on the assention skills. I was able to get around it by opening my passive skill tree and applying points that way. It happens on doors occasionally also, luckily none that are required to open.