Can you effectively focus an element?

Thinking back to Diablo 2, there were mobs on hardest difficulty that were completely immune to things.

This game has something similar? Mobs that are immune to elements, or have ridiculously high resistances to them sometimes?

Or can I build a PURE lightning witch for example, and play her effectively?
Yes it is possible to focus on a certain element. There are no mobs with immunity to a specific kind of elemental damage, of course there are mobs with high resistances but while these can be tough they can be dealt with.

There are quite a few things to demolish enemies with high resistances, curses like Elemental Weakness, gems like lightning penetration and so on allo help to deal with those mobs.
Well that's nice to know. Thanks.

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