POE does not Start Error: Failed to initialise

Try deleting the Content.ggpk file in your Path of Exile folder - See if patching after doing that has any other effect!
Balance & Design
Check that you don't have a firewall or virus checker preventing the game from running something? Try running the game as an administrator?
Balance & Design
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Defragged the files on the SSD? Try IOBITS and let it also do a boot Defrag of the main files.

There is no point defragging an SSD. It just wears it out faster.
Code warrior

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