This Crashing Issue

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If you're frequently getting a "E_OUTOFMEMORY" error when changing areas, you can put -gc 2 at the end of your Path of Exile shortcut (Open the shortcut properties, and add a { -gc 2} after the last quotation mark). If this still doesn't help, try -gc 1. Doing this will increase load times between areas you have visited, and similar areas.