No stupid playstyle required. A tiny desynch into a high damage volatile mob that is about to die right before it blows = rip. OR sometimes they mob was desynched and synchs like 2 rooms back right on top of you (rare, but had it with Dominus today in Residence)..
There are many other scenario's where you can get killed by a desynch even though you played well. But 99% can be avoided by playing well and by using/spamming /oos at the RIGHT times.
But sometimes it pays to be desynched ;). Like spamming SRS/arc around the corner while desynched for a safe igna/aba kill (if you don't have flameblast). Only works while desynched. Then when the server synch you again, you desynch it again on purpose ;). But it can last pretty long sometimes.