It's really tedious to find out what my current DPS is considering all the multipliers and the fact that the tooltip doesn't help, but when I do that I'll share my findings. But I can say that the damage feels really good so far in tier 12 maps. I'll record another video soon so you get a good idea of what it's like.
Currently I am only using 5Ls, but 6Ls would boost damage tremendously. You can see on my character in my profile a lot of my gems are still level 19 and not max quality so I guess that's considerable. If I go with Slower Projectiles I'd have 66.41% more poison damage with a level 20 gem which is pretty substantial. I've been trying to 6L a Vis Mortis but I'm running out of currency to do so unfortunately.
And yeah... I really hope Poison isn't super nerfed like every other meta GGG deconstructs. I'm banking on us still getting 100% chance to poison but without the increased damage on the gem, which if so means we should still have roughly the same or more damage because of Ascendancy classes.